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Front Neuroendocrinol. 2015 Apr;37:76-88. doi: 10.1016/j.yfrne.2014.10.002. Epub 2014 Oct 27.

Photoperiodic time measurement and seasonal immunological plasticity.

Author information

1
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK. Electronic address: tyler.stevenson@abdn.ac.uk.
2
Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, USA.

Abstract

Seasonal variations in immunity are common in nature, and changes in day length are sufficient to trigger enhancement and suppression of immune function in many vertebrates. Drawing primarily on data from Siberian hamsters, this review describes formal and physiological aspects of the neuroendocrine regulation of seasonal changes in mammalian immunity. Photoperiod regulates immunity in a trait-specific manner, and seasonal changes in gonadal hormone secretion and thyroid hormone signaling all participate in seasonal immunomodulation. Photoperiod-driven changes in the hamster reproductive and immune systems are associated with changes in iodothyronine deiodinase-mediated thyroid hormone signaling, but photoperiod exerts opposite effects on select aspects of the epigenetic regulation of reproductive neuroendocrine and lymphoid tissues. Photoperiodic changes in immunocompetence may explain a proportion of the annual variance in disease incidence and severity in nature, and provide a useful framework to help understand brain-immune interactions.

KEYWORDS:

Epigenetic; Hamster; Immune function; Melatonin; Reproduction; Thyroid hormones

PMID:
25456046
PMCID:
PMC4405432
DOI:
10.1016/j.yfrne.2014.10.002
[Indexed for MEDLINE]
Free PMC Article

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