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J Gynecol Obstet Biol Reprod (Paris). 2015 Jan;44(1):10-7. doi: 10.1016/j.jgyn.2014.10.011. Epub 2014 Nov 18.

[Breast and ovarian cancer due to BRCA1&2 hereditary cancer predisposition syndrome and reproduction: literature review].

[Article in French]

Author information

1
Service de gynécologie obstétrique, CHU La Milétrie, 86000 Poitiers, France.
2
Service de gynécologie, CHU Anne-de-Bretagne, 16, boulevard de Bulgarie, BP 90 347, 35203 Rennes cedex 2, France.
3
Service de génétique, CHU Anne-de-Bretagne, 16, boulevard de Bulgarie, BP 90 347, 35203 Rennes cedex 2, France.
4
Service de gynécologie, CHU Anne-de-Bretagne, 16, boulevard de Bulgarie, BP 90 347, 35203 Rennes cedex 2, France. Electronic address: Jean.Leveque@chu-rennes.fr.

Abstract

INTRODUCTION:

Germline mutations BRCA1&2 are responsible in women for breast and ovarian cancers that commonly occur at a young age: as such, there are strong interactions between the oncological risks and the events of reproductive life, pregnancy, breastfeeding, and management of infertility.

MATERIALS AND METHODS:

A review of the international literature from the PubMed database was conducted, and recommendations of French health agencies were exposed. Published studies are case-control and cohort studies in the majority, with a low level of evidence.

RESULTS:

Pregnancy and lactation have no effect on breast and ovaries or even decreases the risk. The sex ratio among patients carrying the mutation is in favor of girls. It is not observed more infertility in patients carrying a mutation despite a strong suspicion of premature ovarian failure, and infertility treatments do not increase breast and ovarian risk. There are ethical debates concerning the place of pre-natal diagnosis: both experts and concerned patients recommend a case-by-case analysis of the requests.

KEYWORDS:

Allaitement maternel; BRCA; Breast and ovarian cancer; Breastfeeding; Cancer du sein et de l’ovaire; Diagnostic pré-implantatoire; Grossesse; Infertility; Infertilité; Pre-natal diagnosis; Pregnancy

PMID:
25455630
DOI:
10.1016/j.jgyn.2014.10.011
[Indexed for MEDLINE]
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