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Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:31-5. doi: 10.1016/j.pnpbp.2014.10.005. Epub 2014 Oct 22.

Effect of tryptophan hydroxylase-2 gene polymorphism G-703 T on personality in a population representative sample.

Author information

1
Division of Neuropsychopharmacology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia.
2
Department of Sport Biology and Physiotherapy, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia.
3
National Institute for Health Development, Estonian Centre of Behavioural and Health Sciences, Hiiu 42, 11619 Tallinn, Estonia.
4
Division of Neuropsychopharmacology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia. Electronic address: jaanus.harro@ut.ee.

Abstract

The tryptophan hydroxylase-2 gene (TPH2) is coding for the key enzyme of serotonin (5-HT) synthesis in the brain and has been associated with a number of psychiatric conditions. A functional variation in the TPH2 gene (G-703T, rs4570625) has been found to affect anxiety-related personality; however, information is very limited regarding the five factor model (FFM) personality traits. We have examined the association of the TPH2 G-703T polymorphism with FFM personality traits, and the possible modulation by the functional variation in the serotonin transporter gene (5-HTTLPR) in a large longitudinal population representative sample. The FFM personality traits were assessed in both birth cohorts of the Estonian Children Personality Behaviour and Health Study at ages 15 (n=742) and 18 (n=834). Significant association of the TPH2 genotype with Neuroticism and Conscientiousness was found at age 15, and with Extraversion and Conscientiousness at age 18. Participants with the T/T genotype scored significantly lower on Neuroticism and higher on Conscientiousness and Extraversion scales. In addition, a gene×gene interaction effect on Conscientiousness was revealed: the TPH2 genotype effect was evident only in the 5-HTTLPR S-allele carriers. These results provide further evidence on the possible role of genetic variations in 5-HT neurotransmission on development of personality traits, and suggest a functional interaction between two key proteins in the 5-HT-ergic system.

KEYWORDS:

5-HTTLPR; Epistasis; Gene×gene interaction; Personality; TPH2 G-703T

PMID:
25455586
DOI:
10.1016/j.pnpbp.2014.10.005
[Indexed for MEDLINE]

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