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Trends Microbiol. 2015 Jan;23(1):22-34. doi: 10.1016/j.tim.2014.10.003. Epub 2014 Nov 14.

Bacterial microcompartments and the modular construction of microbial metabolism.

Author information

1
DOE Plant Research Laboratory, Michigan State University, East Lansing, MI, USA; Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA; Berkeley Synthetic Biology Institute, Berkeley, CA, USA. Electronic address: ckerfeld@lbl.gov.
2
Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, USA.

Abstract

Bacterial microcompartments (BMCs) are protein-bound organelles predicted to be present across 23 bacterial phyla. BMCs facilitate carbon fixation as well as the aerobic and anaerobic catabolism of a variety of organic compounds. These functions have been linked to ecological nutrient cycling, symbiosis, pathogenesis, and cardiovascular disease. Within bacterial cells, BMCs are metabolic modules that can be further dissociated into their constituent structural and functional protein domains. Viewing BMCs as genetic, structural, functional, and evolutionary modules provides a framework for understanding both BMC-mediated metabolism and for adapting their architectures for applications in synthetic biology.

KEYWORDS:

bacterial microcompartments; bacterial organelles; carboxysomes; metabolosomes; synthetic biology

PMID:
25455419
DOI:
10.1016/j.tim.2014.10.003
[Indexed for MEDLINE]

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