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Trends Cell Biol. 2015 Feb;25(2):92-9. doi: 10.1016/j.tcb.2014.10.001. Epub 2014 Nov 7.

Understanding fibroblast heterogeneity in the skin.

Author information

1
Centre for Stem Cells and Regenerative Medicine, King's College London, 28th Floor, Tower Wing, Guy's Hospital Campus, London SE1 9RT, UK.
2
Centre for Stem Cells and Regenerative Medicine, King's College London, 28th Floor, Tower Wing, Guy's Hospital Campus, London SE1 9RT, UK. Electronic address: fiona.watt@kcl.ac.uk.

Abstract

Fibroblasts are found in most tissues, yet they remain poorly characterised. Different fibroblast subpopulations with distinct functions have been identified in the skin. This functional heterogeneity reflects the varied fibroblast lineages that arise from a common embryonic precursor. In addition to autocrine signals, fibroblasts are highly responsive to Wnt-regulated signals from the overlying epidermis, which can act both locally, via extracellular matrix (ECM) deposition, and via secreted factors that impact the behaviour of fibroblasts in different dermal locations. These findings may explain some of the changes that occur in connective tissue during wound healing and cancer progression.

KEYWORDS:

Wnt; adipocytes; connective tissue; dermis; lineage; stem cells

PMID:
25455110
DOI:
10.1016/j.tcb.2014.10.001
[Indexed for MEDLINE]
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