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Curr Biol. 2014 Dec 1;24(23):2797-804. doi: 10.1016/j.cub.2014.09.076. Epub 2014 Oct 30.

Egg-laying demand induces aversion of UV light in Drosophila females.

Author information

1
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
2
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
3
Durham, NC 27705, USA.
4
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: yang@neuro.duke.edu.

Abstract

Drosophila melanogaster females are highly selective about the chemosensory quality of their egg-laying sites, an important trait that promotes the survival and fitness of their offspring. How egg-laying females respond to UV light is not known, however. UV is a well-documented phototactic cue for adult Drosophila, but it is an aversive cue for larvae. Here, we show that female flies exhibit UV aversion in response to their egg-laying demand. First, females exhibit egg-laying aversion of UV: they prefer to lay eggs on dark sites when choosing between UV-illuminated and dark sites. Second, they also exhibit movement aversion of UV: positional tracking of single females suggests that egg-laying demand increases their tendency to turn away from UV. Genetic manipulations of the retina suggest that egg-laying and movement aversion of UV are both mediated by the inner (R7) and not the outer (R1-R6) photoreceptors. Finally, we show that the Dm8 amacrine neurons, a synaptic target of R7 photoreceptors and a mediator of UV spectral preference, are dispensable for egg-laying aversion but essential for movement aversion of UV. This study suggests that egg-laying demand can temporarily convert UV into an aversive cue for female Drosophila and that R7 photoreceptors recruit different downstream targets to control different egg-laying-induced behavioral modifications.

PMID:
25455037
PMCID:
PMC4255361
DOI:
10.1016/j.cub.2014.09.076
[Indexed for MEDLINE]
Free PMC Article

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