New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea

Fitoterapia. 2014 Dec:99:267-75. doi: 10.1016/j.fitote.2014.10.008. Epub 2014 Oct 16.

Abstract

Phytochemical investigation on the stem of Ecdysanthera rosea led to the isolation of eight new C-21 pregnane glycoside ecdysosides A-H (1-8), together with one known pregnane glycoside ecdysantheroside A (9). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D and 2D NMR) analysis, as well as comparison with the reported literature data. Antimicrobial activities of all the compounds were evaluated against bacteria and yeasts. Compounds 1, 9, 3 and 5 exhibited moderate antibacterial activities against respective Enterococcus faecalis and Providensia smartii, with MIC value of 12.5 μg/mL. Compound 8 showed significant anti-yeast activity against Cryptococcus neoformans with MIC value of 12.5 μg/mL.

Keywords: Antimicrobial activity; Apocynaceae; Ecdysanthera rosea; Pregnane glycosides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification
  • Apocynaceae / chemistry*
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plant Stems / chemistry
  • Pregnanes / chemistry*
  • Pregnanes / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Glycosides
  • Pregnanes
  • pregnane glycoside