Send to

Choose Destination
Dev Cogn Neurosci. 2015 Feb;11:129-44. doi: 10.1016/j.dcn.2014.10.003. Epub 2014 Oct 23.

Saguenay Youth Study: a multi-generational approach to studying virtual trajectories of the brain and cardio-metabolic health.

Author information

Rotman Research Institute, University of Toronto, Toronto, Canada. Electronic address:
Hospital for Sick Children, University of Toronto, Toronto, Canada. Electronic address:
McGill University Health Centre, McGill University, Montreal, Canada.
Community Genomic Medicine Centre, Department of Medicine, Université de Montréal, Chicoutimi, Canada.
Montreal Neurological Institute, McGill University, Montreal, Canada.
Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Department of Health Sciences, University of Quebec in Chicoutimi, Chicoutimi, Canada.


This paper provides an overview of the Saguenay Youth Study (SYS) and its parental arm. The overarching goal of this effort is to develop trans-generational models of developmental cascades contributing to the emergence of common chronic disorders, such as depression, addictions, dementia and cardio-metabolic diseases. Over the past 10 years, we have acquired detailed brain and cardio-metabolic phenotypes, and genome-wide genotypes, in 1029 adolescents recruited in a population with a known genetic founder effect. At present, we are extending this dataset to acquire comparable phenotypes and genotypes in the biological parents of these individuals. After providing conceptual background for this work (transactions across time, systems and organs), we describe briefly the tools employed in the adolescent arm of this cohort and highlight some of the initial accomplishments. We then outline in detail the phenotyping protocol used to acquire comparable data in the parents.


Addiction; Adolescence; Brain; MRI; Mental health; Middle age

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center