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Osteoarthritis Cartilage. 2015 Mar;23(3):331-3. doi: 10.1016/j.joca.2014.11.022. Epub 2014 Nov 29.

Smoking and osteoarthritis: a review of the evidence and its implications.

Author information

1
Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, USA; NIHR Biomedical Research Unit, University of Manchester, Manchester, UK. Electronic address: dfelson@bu.edu.
2
Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, USA.

Abstract

A number of reports including a recent publication in Osteoarthritis and Cartilage have suggested that smokers have a lower than expected prevalence of osteoarthritis (OA) than nonsmokers. We review the evidence linking smoking with OA, suggest approaches whereby the direct and indirect effects of smoking on OA might be distinguished, highlight two diseases, ulcerative colitis and Parkinson's disease, where smoking is protective, discuss mechanisms by which nicotine might act and lastly explore the association of smoking with enhanced musculoskeletal pain.

KEYWORDS:

Nicotine; Osteoarthritis; Smoking

PMID:
25454371
PMCID:
PMC5473429
DOI:
10.1016/j.joca.2014.11.022
[Indexed for MEDLINE]
Free PMC Article

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