Format

Send to

Choose Destination
See comment in PubMed Commons below
Behav Brain Res. 2015 Feb 1;278:375-84. doi: 10.1016/j.bbr.2014.10.011. Epub 2014 Oct 22.

Updating memories--the role of prediction errors in memory reconsolidation.

Author information

1
School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
2
School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom; School of Psychology, University of New South Wales, Kensington, Sydney 2052, NSW, Australia. Electronic address: a.reichelt@unsw.edu.au.

Abstract

Memories are not static imprints of past experience, but rather are dynamic entities which enable us to predict outcomes of future situations and inform appropriate behaviours. In order to maintain the relevance of existing memories to our daily lives, memories can be updated with new information via a process of reconsolidation. In this review we describe recent experimental advances in the reconsolidation of both appetitive and aversive memory, and explore the neuronal mechanisms that underpin the conditions under which reconsolidation will occur. We propose that a prediction error signal, originating from dopaminergic midbrain neurons, is necessary for destabilisation and subsequent reconsolidation of a memory.

KEYWORDS:

Dopamine; Memory; NMDAR; Prediction error; Reconsolidation

PMID:
25453746
DOI:
10.1016/j.bbr.2014.10.011
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center