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Clin Neurophysiol. 2015 Jul;126(7):1310-8. doi: 10.1016/j.clinph.2014.10.012. Epub 2014 Oct 18.

Impaired pre-attentive auditory processing in fibromyalgia: A mismatch negativity (MMN) study.

Author information

1
Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences, Seoul, Republic of Korea; MEG Center, Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea.
2
MEG Center, Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea; Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea.
3
MEG Center, Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea; Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea.
4
MEG Center, Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
5
Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences, Seoul, Republic of Korea; MEG Center, Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea; Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea. Electronic address: chungc@snu.ac.kr.

Abstract

OBJECTIVE:

Fibromyalgia (FM) patients often show deficits in cognitive functions such as attention and working memory. We assumed that pre-attentive information processing, a crucial element in human perception and cognition, would be altered in FM patients. Thus, the objective of this study was to determine whether FM patients exhibit alterations in pre-attentive processing as assessed by auditory mismatch negativity (MMN).

METHODS:

Auditory evoked magnetic fields were recorded in FM patients (n=18) and healthy control subjects (n=21) during a duration-deviant auditory oddball paradigm. The magnetic mismatch negativity (MMNm) was obtained by subtracting responses to standard tones from responses to deviant tones. Pressure pain thresholds over the thenar and trapezius muscles were determined using an algometer.

RESULTS:

MMNm peak amplitudes in right hemispheres were attenuated, and the directional asymmetry coefficient of the MMNm amplitude was lower in FM patients, indicating a more leftward asymmetry than in healthy control subjects. Smaller right MMNm amplitude was associated with lower pressure pain thresholds of thenar muscles in FM patients.

CONCLUSIONS:

Our results suggested that pre-attentive processing of auditory information is impaired in FM patients.

SIGNIFICANCE:

This study provided neurophysiological evidence of impaired pre-attentive sensory change detection in FM.

KEYWORDS:

Auditory evoked fields; Chronic pain; Fibromyalgia; Magnetoencephalography; Mismatch negativity (MMN)

PMID:
25453609
DOI:
10.1016/j.clinph.2014.10.012
[Indexed for MEDLINE]

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