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Mol Neurobiol. 2015 Dec;52(3):1430-1439. doi: 10.1007/s12035-014-8929-9. Epub 2014 Oct 28.

Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia-Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism.

Author information

1
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
2
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China. liyuwenzs@gmail.com.
3
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China. adwen-2004@hotmail.com.

Abstract

Oxidative stress is well known to play a pivotal role in cerebral ischemia-reperfusion injury. The nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway has been considered a potential target for neuroprotection in stroke. 11-Keto-β-boswellic acid (KBA) is a triterpenoid compound from extracts of Boswellia serrata. The aim of the present study was to determine whether KBA, a novel Nrf2 activator, can protect against cerebral ischemic injury. Middle cerebral artery occlusion (MCAO) was operated on male Sprague-Dawley rats. KBA (25 mg/kg) applied 1 h after reperfusion significantly reduced infarct volumes and apoptotic cells as well as increased neurologic scores at 48 h after reperfusion. Meanwhile, posttreatment with KBA significantly decreased malondialdehyde (MDA) levels, restored the superoxide dismutase (SOD) activity, and increased the protein Nrf2 and HO-1 expression in brain tissues. In primary cultured astrocytes, KBA increased the Nrf2 and HO-1 expression, which provided protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. But knockdown of Nrf2 or HO-1 attenuated the protective effect of KBA. In conclusion, these findings provide evidence that the neuroprotection of KBA against oxidative stress-induced ischemic injury involves the Nrf2/HO-1 pathway.

KEYWORDS:

11-Keto-β-boswellic acid; Antioxidants; HO-1; MCAO; Nrf2; Oxygen glucose deprivation

PMID:
25452227
DOI:
10.1007/s12035-014-8929-9
[Indexed for MEDLINE]

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