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Int J Biol Markers. 2015 Feb 24;30(1):e88-95. doi: 10.5301/jbm.5000125.

FBXW7 mutation analysis and its correlation with clinicopathological features and prognosis in colorectal cancer patients.

Author information

1
Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei - Taiwan.

Abstract

PURPOSE:

This study aimed to determine the prognostic value of mutations in the tumor suppressor gene FBXW7 for clinical outcomes in colorectal cancer (CRC).

METHODS:

Between January 2000 and December 2009, FBXW7 mutations in tumor tissues from 1,519 CRC patients at Taipei Veterans General Hospital were assessed using a MassArray system. We compared the clinicopathological variables and prognosis between the wild-type and mutant tumor tissue groups.

RESULTS:

FBXW7 mutations were present in 114/1,519 CRC patients (7.5%). In stage I/II CRC patients, mutant FBXW7 was more common than wild-type FBXW7 (62.3% vs. 50.8%). CRC patients with FBXW7 mutations did not differ significantly in their 5-year overall survival (OS). Stage I/II CRC patients with FBXW7 mutations had lower OS, but this difference was not significant (71.6% vs. 78.2%). Among FBXW7 tumors, S582L was the most frequent mutation type (19.3%), followed by R465H (16.6%), R505C (14.9%) and R479Q (14.9%). Subgroup analysis of FBXW7 mutants showed that R465H/R465C/R479Q had better 5-year OS than other mutant types (76.9% vs. 56.0%; p=0.012).

CONCLUSIONS:

There was no strong association between patient prognosis and FBXW7 mutations in our large-scale study.

PMID:
25450649
DOI:
10.5301/jbm.5000125
[Indexed for MEDLINE]

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