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J Biotechnol. 2015 Feb 10;195:72-3. doi: 10.1016/j.jbiotec.2014.07.441. Epub 2014 Nov 5.

Genome sequence of type strain Paenibacillus polymyxa DSM 365, a highly efficient producer of optically active (R,R)-2,3-butanediol.

Author information

1
National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Academy of Sciences, No. 98 Da-ling Road, Nanning 530007, China.
2
Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickestrasse 15, Hamburg 21073, Germany.
3
CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, NO. 1 Beichen West Road, Beijing 100101, China.
4
National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Academy of Sciences, No. 98 Da-ling Road, Nanning 530007, China. Electronic address: rbhuang@gxas.ac.cn.

Abstract

Paenibacillus polymyxa DSM 365, an efficient producer of (R,R)-2,3-butanediol, is known to show the highest production titer and productivity reported to date. Here, the first draft genome sequence of this promising strain may provide the genetic basis for further insights into the molecular mechanisms underlying the production of (R,R)-2,3-butanediol with high optical purity and at a high titer. It will also facilitate the design of rational strategies for further strain improvements, as well as construction of artificial biosynthetic pathways through synthetic biology for asymmetric synthesis of chiral 2,3-butanediol or acetoin in common microbial hosts.

KEYWORDS:

(R,R)-2,3-butanediol; Genome sequence; High optical purity; Paenibacillus polymyxa

PMID:
25450636
DOI:
10.1016/j.jbiotec.2014.07.441
[Indexed for MEDLINE]

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