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Biochim Biophys Acta. 2015 Jan;1855(1):24-42. doi: 10.1016/j.bbcan.2014.10.005. Epub 2014 Oct 28.

Regulation of cancer metastasis by cell-free miRNAs.

Author information

1
Department of Molecular Biology, Princeton University, Princeton NJ 08544, USA.
2
Department of Molecular Biology, Princeton University, Princeton NJ 08544, USA. Electronic address: ykang@princeton.edu.

Abstract

MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer initiation and metastatic progression, both by promoting and suppressing metastasis. Recently, cell-free miRNAs shed from cancer cells into circulation have been reported in cancer patients, raising hope for development of novel biomarkers that can be routinely measured in easily accessible samples. In fact, establishing miRNA expression in the circulation likely has advantages over determination in primary tumor tissue, further augmenting the potential applications of miRNA detection in oncological practice. In addition, secretion of miRNAs impacting distant cell signaling or promoting the formation of a niche that sustains a distant tumor microenvironment allows for new treatment approaches to thwart cancer progression.

KEYWORDS:

Biomarker; Body fluids; Cell-free microRNA; Exosomes; Metastasis

PMID:
25450578
PMCID:
PMC4312713
DOI:
10.1016/j.bbcan.2014.10.005
[Indexed for MEDLINE]
Free PMC Article

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