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Biochem Biophys Res Commun. 2014 Oct 31;453(4):821-5. doi: 10.1016/j.bbrc.2014.10.036. Epub 2014 Oct 14.

Cofilin-1 is involved in regulation of actin reorganization during influenza A virus assembly and budding.

Author information

1
Division of Molecular Pharmacology of Infectious Agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 852-8521 Nagasaki, Japan.
2
Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, Guangdong, China.
3
Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, Guangdong, China. Electronic address: twang-yf@163.com.
4
Division of Molecular Pharmacology of Infectious Agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 852-8521 Nagasaki, Japan. Electronic address: kkholi@nagasaki-u.ac.jp.

Abstract

Influenza A virus (IAV) assembly and budding on host cell surface plasma membrane requires actin cytoskeleton reorganization. The underlying molecular mechanism involving actin reorganization remains unclarified. In this study, we found that the natural antiviral compound petagalloyl glucose (PGG) inhibits F-actin reorganization in the host cell membrane during the late stage of IAV infection, which are associated with the suppression of total cofilin-1 level and its phosphorylation. Knock-down of cofilin-1 reduces viral yields. These findings provide the first evidence that cofilin-1 plays an important role in regulating actin reorganization during IAV assembly and budding.

KEYWORDS:

Cofilin-1; F-actin; Influenza A virus; Pentagalloyl glucose; Viral assembly; Viral budding

PMID:
25450354
DOI:
10.1016/j.bbrc.2014.10.036
[Indexed for MEDLINE]

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