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Mov Disord. 2015 Jan;30(1):45-53. doi: 10.1002/mds.26103. Epub 2014 Dec 1.

Presynaptic effects of levodopa and their possible role in dyskinesia.

Author information

1
Departments of Neurology, Columbia University Medical Center, New York, New York, USA.

Abstract

Levodopa replacement therapy has long provided the most effective treatment for Parkinson's disease (PD). We review how this dopamine (DA) precursor enhances dopaminergic transmission by providing a greater sphere of neurotransmitter influence as a result of the confluence of increased quantal size and decreased DA reuptake, as well as loading DA as a false transmitter into surviving serotonin neuron synaptic vesicles. We further review literature on how presynaptic dysregulation of DA release after l-dopa might trigger dyskinesias in PD patients.

KEYWORDS:

Parkinson's Disease; dopamine; dyskinesia; levodopa; presynaptic; serotonin

PMID:
25450307
PMCID:
PMC4314471
DOI:
10.1002/mds.26103
[Indexed for MEDLINE]
Free PMC Article

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