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Fertil Steril. 2015 Jan;103(1):184-9. doi: 10.1016/j.fertnstert.2014.10.001. Epub 2014 Oct 22.

A prospective study of prepregnancy serum concentrations of perfluorochemicals and the risk of gestational diabetes.

Author information

1
Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland. Electronic address: zhangcu@mail.nih.gov.
2
Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland.
3
Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia.
4
Department of Occupational and Environmental Health and Rollins School of Public Health, Emory University, Atlanta, Georgia.

Abstract

OBJECTIVE:

To examine preconception serum concentrations of perfluorooctanoic acid (PFOA) and six other PFCs in relation to gestational diabetes (GDM) risk.

DESIGN:

Prospective cohort with longitudinal follow-up.

SETTING:

Not applicable.

PATIENT(S):

Among 501 women recruited upon discontinuing contraception for the purpose of becoming pregnant, 258 (51%) became pregnant and were eligible for the study, of which 28 (11%) reported having physician-diagnosed GDM during follow-up.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

The odds ratios (ORs) and 95% confidence intervals (CIs) of GDM associated with each standard deviation (SD) increment of preconception serum PFOA concentration (ng/mL, log-transformed) and six other PFCs were estimated with the use of logistic regression after adjusting for age, prepregnancy body mass index, smoking, and parity conditional on gravidity.

RESULT(S):

Preconception geometric mean (95% CI) PFOA concentrations (in ng/mL) were higher for women with than without GDM (3.94 [3.15-4.93] vs. 3.07 [2.83-3.12], respectively). Each SD increment in PFOA was associated with a 1.87-fold increased GDM risk (adjusted OR 1.86 [95% CI 1.14-3.02]). A slightly increased risk associated with each SD increment for the six other PFCs was observed as well (all ORs >1.0, range 1.06-1.27), although the associations were not statistically significant.

CONCLUSION(S):

Our findings suggested that higher environmentally relevant concentrations of PFOA were significantly associated with an increased risk of GDM. If corroborated, these findings may be suggestive of a possible environmental etiology for GDM.

KEYWORDS:

Perfluorochemicals (PFCs); gestational diabetes; perfluorooctanoic acid (PFOA); pregnancy

PMID:
25450302
PMCID:
PMC4282598
DOI:
10.1016/j.fertnstert.2014.10.001
[Indexed for MEDLINE]
Free PMC Article

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