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Mol Cell Endocrinol. 2015 Jun 15;408:138-44. doi: 10.1016/j.mce.2014.10.022. Epub 2014 Oct 31.

How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors.

Author information

1
Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, Sophia Antipolis, Valbonne, France; Laboratoire International Associé (LIA) CNRS NEOGENEX, Sophia Antipolis, Valbonne, France; Université de Nice, Sophia Antipolis, Valbonne, France.
2
Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, Sophia Antipolis, Valbonne, France; Laboratoire International Associé (LIA) CNRS NEOGENEX, Sophia Antipolis, Valbonne, France; Université de Nice, Sophia Antipolis, Valbonne, France. Electronic address: ninino@ipmc.cnrs.fr.

Abstract

SF-1 and LRH-1 are transcription factors that belong to the NR5A family of nuclear receptors that both have an essential role during development. Recent studies at the genome-wide scale have enabled the characterization of the cistrome and transcriptome regulated by SF-1 and LRH-1 in different cell lines and tissues. Those studies have allowed us to make a significant leap forward in our understanding of the mechanisms of transcriptional regulation of NR5A nuclear receptors in stem cells and cancer.

KEYWORDS:

Adrenal cortex; Endocrine cancers; Nuclear receptors; Transcription factors

PMID:
25449416
DOI:
10.1016/j.mce.2014.10.022
[Indexed for MEDLINE]

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