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Physiol Behav. 2015 Feb;139:202-9. doi: 10.1016/j.physbeh.2014.11.025. Epub 2014 Nov 14.

Effects of sugar solutions on hypothalamic appetite regulation.

Author information

1
Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, United States.
2
Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, United States. Electronic address: twc@umd.edu.

Abstract

Several hypotheses for the causes of the obesity epidemic in the US have been proposed. One such hypothesis is that dietary intake patterns have significantly shifted to include unprecedented amounts of refined sugar. We set out to determine if different sugars might promote changes in the hypothalamic mechanisms controlling food intake by measuring several hypothalamic peptides subsequent to overnight access to dilute glucose, sucrose, high fructose corn syrup, or fructose solutions. Rats were given access to food, water and a sugar solution for 24h, after which blood and tissues were collected. Fructose access (as opposed to other sugars that were tested) resulted in a doubling of circulating triglycerides. Glucose consumption resulted in upregulation of 7 satiety-related hypothalamic peptides whereas changes in gene expression were mixed for remaining sugars. Also, following multiple verification assays, 6 satiety related peptides were verified as being affected by sugar intake. These data provide evidence that not all sugars are equally effective in affecting the control of intake.

KEYWORDS:

Food intake; Fructose; Glucose; High fructose corn syrup; Obesity; Sucrose

PMID:
25449399
DOI:
10.1016/j.physbeh.2014.11.025
[Indexed for MEDLINE]

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