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FEBS Lett. 2014 Nov 28;588(23):4438-47.

MiR-185 is involved in human breast carcinogenesis by targeting Vegfa.

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Haidian Maternal & Child Health Hospital, Beijing, China; Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, China; Graduate School, Peking Union Medical College, Beijing, China.


MiR-185 expression has been associated with many cancers. However, the roles of miR-185 in human breast cancer remain elusive. Here, we found that miR-185 expression was decreased in human breast cancer tissues compared with healthy tissue controls. Up-regulation of miR-185 inhibited breast cancer cell proliferation and invasion and vice versa. MiR-185 was shown to bind to the 3′-untranslated region (UTR) of vascular endothelial growth factor a (Vegfa), and a significant inverse correlation was found between miR-185 and Vegfa. Vegfa overexpression partially restored the inhibition of cell proliferation and invasion that was induced by miR-185, and vice versa. Additionally, Vegfa expression was found to be high in human breast cancer tissues. Thus, miR-185-mediated Vegfa targeting may be involved in breast cancer formation.

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