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Drug Discov Today. 2015 Apr;20(4):406-10. doi: 10.1016/j.drudis.2014.10.017. Epub 2014 Nov 7.

New drugs from ancient natural foods. Oleocanthal, the natural occurring spicy compound of olive oil: a brief history.

Author information

1
Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases Department, Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
2
Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases Department, Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain; Department of Molecular and Cellular Biology, University of A Coruña, A Coruña, Spain.
3
Servizo Galego de Saude, Division of Orthopaedics Surgery and Traumatology, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
4
Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Laboratory of Molecular and Cellular Cardiology, Research Laboratory 7, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
5
Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA; Monell Chemical Senses Center, Philadelphia, PA, USA.
6
Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain; Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Division of Rheumatology, Santiago University Clinical Hospital, Santiago de Compostela, Spain.
7
Servizo Galego de Saude, Instituto de Investigación Sanitaria de Santiago, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases Department, Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain. Electronic address: oreste.gualillo@sergas.es.

Abstract

Extra-virgin olive oil (EVOO), a principal component of the Mediterranean diet (Med diet), is one of the most ancient known foods and has long been associated with health benefits. Many phenolic compounds extracted from Olea europea L. have attracted attention since their discovery. Among these phenolic constituents, oleocanthal has recently emerged as a potential therapeutic molecule for different diseases, showing relevant pharmacological properties in various pathogenic processes, including inflammation, cancers and neurodegenerative diseases. Here, we discuss and summarize the most recent pharmacological evidence for the medical relevance of oleocanthal, focusing our attention on its anti-inflammatory and chemotherapeutic roles.

PMID:
25448758
DOI:
10.1016/j.drudis.2014.10.017
[Indexed for MEDLINE]

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