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Pharmacol Res. 2015 Feb;92:6-12. doi: 10.1016/j.phrs.2014.10.005. Epub 2014 Oct 29.

Is narcolepsy a classical autoimmune disease?

Author information

1
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel; Center for Autoimmune Diseases Research - CREA, Universidad del Rosario, Bogota, Colombia; Doctoral Program in Biomedical Sciences, Universidad del Rosario, Bogota, Colombia.
2
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel; Rheumatic Disease Unit, Sheba Medical Center, Tel-Hashomer, Israel; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2013, Sheba Medical Center, Tel-Hashomer, Israel.
3
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel; Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel Aviv University, Israel. Electronic address: shoenfel@post.tau.ac.il.

Abstract

Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin producing neurons in the lateral hypothalamus. Current evidences suggest an autoimmune mediated process causing the specific loss of orexin neurons. The high association of the disease with the HLA DQB1*06:02, as well as the link with environmental factors and are important clues supporting this theory. Recently, the association between the occurrence of the disease and vaccination campaign after the 2009 H1N1 pandemic highlighted the importance to increase the knowledge in the Pandora box of the vaccines. This review discusses the last finding regarding the pathogenesis of the disease and its relationship with the H1N1 vaccines.

KEYWORDS:

ASIA syndrome; Adjuvant; Autoimmune diseases; H1N1; Infections; Narcolepsy

PMID:
25447795
DOI:
10.1016/j.phrs.2014.10.005
[Indexed for MEDLINE]

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