Format

Send to

Choose Destination
Pharmacol Res. 2015 Jan;91:1-8. doi: 10.1016/j.phrs.2014.10.007. Epub 2014 Nov 3.

Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement.

Author information

1
Department of Periodontology, Dental School, University of Sevilla, Spain; Research Laboratory, Dental School, University of Sevilla, Sevilla, Spain.
2
Research Laboratory, Dental School, University of Sevilla, Sevilla, Spain.
3
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Ancona 60131, Italy; Area de Nutrición y Salud, Universidad Internacional Iberoamericana (UNINI), Campeche C.P. 24040, Mexico; Facultad de Ciencias de la Salud, Universidad Nacional de Chimborazo, Riobamba, Ecuador.
4
Dipartimento di Scienze Agrarie, Alimentari e Ambientali (D3A), Università Politecnica delle Marche, Via Ranieri 65, Ancona 60131, Italy.
5
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Ancona 60131, Italy; Director Centre for Nutrition & Health, Universidad Europea del Atlantico (UEA), Santander 39011, Spain. Electronic address: m.a.battino@univpm.it.
6
Research Laboratory, Dental School, University of Sevilla, Sevilla, Spain. Electronic address: mdcormor@us.es.

Abstract

Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxygen consumption and mitochondrial biogenesis. After comparing coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), we observed a more significant protection of CoQ10 than of NAC, which was comparable with other lipophilic and hydrophilic antioxidants such as vitamin E or BHA respectively. CoQ10 improved mitochondrial biogenesis by activating PGC-1α and TFAM. This lipophilic antioxidant protection was observed in mice after LPS injection. These results show that mitochondria-targeted lipophilic antioxidants could be a possible specific therapeutic strategy in pharmacology in the treatment of infectious diseases and their complications.

KEYWORDS:

Coenzyme Q(10); Lipopolysaccharide; Mitochondria; N-acetylcysteine; Porphyromonas gingivalis

PMID:
25447593
DOI:
10.1016/j.phrs.2014.10.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center