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Biochim Biophys Acta. 2015 Jan;1852(1):47-52. doi: 10.1016/j.bbadis.2014.11.003. Epub 2014 Nov 8.

Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure.

Author information

1
Animal Science, College of Agriculture and Natural Resources, University of WY, Laramie WY82071, USA; Department of Cardiology, Xi Jing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
2
Center for Cardiovascular Research and Alternative Medicine, College of Health Science, University of WY, Laramie WY82071, USA.
3
Animal Science, College of Agriculture and Natural Resources, University of WY, Laramie WY82071, USA; Center for Cardiovascular Research and Alternative Medicine, College of Health Science, University of WY, Laramie WY82071, USA. Electronic address: wguo3@uwyo.edu.

Abstract

Sarcomeric protein isoforms are mainly governed by alternative promoter-driven expression, distinct gene expression, gene mutation and alternative mRNA splicing. The transitions of sarcomeric proteins have been implicated to play a role in the onset and development of human heart failure. In this mini-review, we summarized isoform transitions of several most widely examined sarcomeric proteins including myosin, actin, troponin, tropomyosin, titin and myosin binding protein-C, and the consequence of these abnormal isoform transitions. Even though the isoform transitions of sarcomeric proteins have been described in individual sarcomeric protein reviews, no concise summary of these results has been presented previously. This review is intended to fill this gap and discuss possible future perspectives.

KEYWORDS:

Alternative splicing; Heart failure; Protein isoform transition; Sarcomere proteins

PMID:
25446994
PMCID:
PMC4268308
DOI:
10.1016/j.bbadis.2014.11.003
[Indexed for MEDLINE]
Free PMC Article

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