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Biochim Biophys Acta. 2015 Jun;1852(6):1137-44. doi: 10.1016/j.bbadis.2014.11.012. Epub 2014 Nov 18.

Resveratrol and obesity: Can resveratrol relieve metabolic disturbances?

Author information

1
Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200MD Maastricht, The Netherlands.
2
Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200MD Maastricht, The Netherlands. Electronic address: p.schrauwen@maastrichtuniversity.nl.

Abstract

There is an increasing need for novel preventive and therapeutic strategies to combat obesity and related metabolic disorders. In this respect, the natural polyphenol resveratrol has attracted significant interest. Animal studies indicate that resveratrol mimics the effects of calorie restriction via activation of sirtuin 1 (SIRT1). SIRT1 is an important player in the regulation of cellular energy homeostasis and mitochondrial biogenesis. Rodent studies have shown beneficial effects of resveratrol supplementation on mitochondrial function, glucose metabolism, body composition and liver fat accumulation. However, confirmation of these beneficial effects in humans by placebo-controlled clinical trials remains relatively limited. This review will give an overview of pre-clinical and clinical studies examining the effects of resveratrol on obesity-induced negative health outcomes. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.

KEYWORDS:

Mitochondria; Obesity; Resveratrol; Sirtuin; Type 2 diabetes

PMID:
25446988
DOI:
10.1016/j.bbadis.2014.11.012
[Indexed for MEDLINE]
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