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Arch Med Res. 2014 Nov;45(8):677-86. doi: 10.1016/j.arcmed.2014.11.010. Epub 2014 Nov 20.

Role of histaminergic system in blood-brain barrier dysfunction associated with neurological disorders.

Author information

1
Department of Pharmacobiology, Center of Research and Advanced Studies, Mexico City, Mexico.
2
Unit of Medical Research in Neurological Diseases, National Medical Center, Mexico City, Mexico.
3
Department of Pharmacobiology, Center of Research and Advanced Studies, Mexico City, Mexico. Electronic address: lrocha@cinvestav.mx.

Abstract

Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outside elements from blood to the central nervous system (CNS) that may trigger a cascade of events that leads to neuroinflammation. In this review, evidence that mast cells and the release of factors such as histamine play an important role in the neuroinflammatory process associated with brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy is presented.

KEYWORDS:

Blood–brain barrier; Histamine; Mast cells; Neuroinflammation; Neurological disorders

PMID:
25446620
DOI:
10.1016/j.arcmed.2014.11.010
[Indexed for MEDLINE]

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