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Phytochemistry. 2014 Dec;108:171-6. doi: 10.1016/j.phytochem.2014.09.022. Epub 2014 Oct 18.

Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus.

Author information

1
College of Pharmaceutical Science, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310014, PR China.
2
Institute of Biotechnology, Hangzhou East China Pharmaceutical Group, 866 Moganshan Road, Hangzhou 310011, PR China.
3
College of Pharmaceutical Science, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310014, PR China. Electronic address: tianranyaowu@zjut.edu.cn.
4
College of Pharmaceutical Science, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310014, PR China. Electronic address: zjnpr@zjut.edu.cn.

Abstract

Lanostane-type triterpenoids, inotolactones A and B, a drimane-type sesquiterpenoid, inotolactone C, and five known terpenoids 6β-hydroxy-trans-dihydroconfertifolin, inotodiol, 3β,22-dihydroxyanosta-7,9(11),24-triene, 3β-hydroxycinnamolide, and 17-hydroxy-ent-atisan-19-oic acid, were isolated from the submerged culture of chaga mushroom, Inonotus obliquus. Their structures were characterized by spectroscopic methods, including MS and NMR (1D and 2D) spectroscopic techniques. Inotolactones A and B, examples of lanostane-type triterpenoids bearing α,β-dimethyl, α,β-unsaturated δ-lactone side chains, exhibited more potent alpha-glucosidase inhibitory activities than the positive control acarbose. This finding might be related to the anti-hyperglycemic properties of the fungus and to its popular role as a diabetes treatment. In addition, a drimane-type sesquiterpenoid and an atisane-type diterpenoid were isolated from I. obliquus.

KEYWORDS:

Alpha-glucosidase; Chaga mushroom; Drimane; Hymenochaetaceae; Inonotus obliquus; Lanostane; Triterpenoids

PMID:
25446238
DOI:
10.1016/j.phytochem.2014.09.022
[Indexed for MEDLINE]

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