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Adv Drug Deliv Rev. 2015 Mar;82-83:160-7. doi: 10.1016/j.addr.2014.11.010. Epub 2014 Nov 14.

Peripheral nerve regeneration: experimental strategies and future perspectives.

Author information

1
Blond McIndoe Laboratories, Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
2
Blond McIndoe Laboratories, Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Manchester, UK; Materials Science Centre, School of Materials, The University of Manchester, Manchester, UK.
3
Section for Anatomy, Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.
4
Blond McIndoe Laboratories, Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Manchester, UK; Department of Plastic Surgery & Burns, University Hospital of South Manchester, Manchester, UK. Electronic address: adam.reid@manchester.ac.uk.

Abstract

Peripheral nerve injuries represent a substantial clinical problem with insufficient or unsatisfactory treatment options. This review summarises all the events occurring after nerve damage at the level of the cell body, the site of injury and the target organ. Various experimental strategies to improve neuronal survival, axonal regeneration and target reinnervation are described including pharmacological approaches and cell-based therapies. Given the complexity of nerve regeneration, further studies are needed to address the biology of nerve injury, to improve the interaction with implantable scaffolds, and to implement cell-based therapies in nerve tissue engineering.

KEYWORDS:

Muscle denervation; Neuronal survival; Peripheral nerve regeneration; Reinnervation; Scaffold; Stem cell

PMID:
25446133
DOI:
10.1016/j.addr.2014.11.010
[Indexed for MEDLINE]

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