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Neurotoxicol Teratol. 2015 Jan-Feb;47:96-101. doi: 10.1016/j.ntt.2014.11.001. Epub 2014 Nov 8.

Association of lifetime exposure to fluoride and cognitive functions in Chinese children: a pilot study.

Author information

1
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. Electronic address: achoi@hsph.harvard.edu.
2
School of Stomatology, China Medical University, Shenyang, China.
3
School of Public Health, China Medical University, Shenyang, China.
4
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Department of Neurology, Children's Hospital, Boston, USA.
5
Mianning Center for Disease Control and Prevention, Xichang, Sichuan, China.
6
Sichuan Center for Disease Control and Prevention, Chengdu, Sichuan, China.
7
Center for Disease Control and Prevention of Liangshan Perfecture, Xichang, Sichuan, China.
8
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Institute of Public Health, University of Southern Denmark, Odense, Denmark.

Erratum in

  • Neurotoxicol Teratol. 2015 Sep-Oct;51():89.

Abstract

BACKGROUND:

A systematic review and meta-analysis of published studies on developmental fluoride neurotoxicity support the hypothesis that exposure to elevated concentrations of fluoride in water is neurotoxic during development.

METHODS:

We carried out a pilot study of 51 first-grade children in southern Sichuan, China, using the fluoride concentration in morning urine after an exposure-free night; fluoride in well-water source; and dental fluorosis status as indices of past fluoride exposure. We administered a battery of age-appropriate, relatively culture-independent tests that reflect different functional domains: the Wide Range Assessment of Memory and Learning (WRAML), Wechsler Intelligence Scale for Children-Revised (WISC-IV) digit span and block design; finger tapping and grooved pegboard. Confounder-adjusted associations between exposure indicators and test scores were assessed using multiple regression models.

RESULTS:

Dental fluorosis score was the exposure indicator that had the strongest association with the outcome deficits, and the WISC-IV digit span subtest appeared to be the most sensitive outcome, where moderate and severe fluorosis was associated with a digit span total score difference of -4.28 (95% CI -8.22, -0.33) and backward score with -2.13 (95% CI -4.24, -0.02).

CONCLUSIONS:

This pilot study in a community with stable lifetime fluoride exposures supports the notion that fluoride in drinking water may produce developmental neurotoxicity, and that the dose-dependence underlying this relationship needs to be characterized in detail.

KEYWORDS:

Children; Confounding; Fluoride; Fluorosis; Neuropsychological measures; Prenatal exposure delayed effects

Comment in

PMID:
25446012
DOI:
10.1016/j.ntt.2014.11.001
[Indexed for MEDLINE]

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