Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin

J Antibiot (Tokyo). 1989 Jun;42(6):837-45. doi: 10.7164/antibiotics.42.837.

Abstract

A strain of Streptoverticillium cinnamoneum produced a peptide antibiotic named lanthiopeptin, which contained four unusual amino acids, erythro-beta-hydroxyaspartic acid, mesolanthionine, threo-beta-methyllanthionine and lysinoalanine. Lanthiopeptin showed antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells by cytopathic effect reduction assay. The structure of lanthiopeptin is similar to that of ancovenin.

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / analysis
  • Animals
  • Anti-Bacterial Agents* / analysis
  • Anti-Bacterial Agents* / biosynthesis
  • Anti-Bacterial Agents* / isolation & purification*
  • Anti-Bacterial Agents* / pharmacology
  • Antifungal Agents / analysis
  • Antifungal Agents / biosynthesis
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Antiviral Agents / analysis
  • Antiviral Agents / biosynthesis
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Bacteria / drug effects
  • Chromatography, Gel
  • Cytopathogenic Effect, Viral / drug effects
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Peptide Biosynthesis
  • Peptides / analysis
  • Peptides / isolation & purification*
  • Peptides / pharmacology
  • Peptides, Cyclic
  • Simplexvirus / drug effects*
  • Soil Microbiology
  • Solubility
  • Spores, Bacterial
  • Streptomycetaceae / growth & development
  • Streptomycetaceae / metabolism*
  • Streptomycetaceae / physiology
  • Vero Cells

Substances

  • Amino Acids
  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antiviral Agents
  • Peptides
  • Peptides, Cyclic
  • lanthiopeptin