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J Pediatr. 2015 Jan;166(1):191-4. doi: 10.1016/j.jpeds.2014.09.019. Epub 2014 Oct 23.

Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.

Author information

1
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
2
Department of Pediatric Endocrinology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
3
Department of Pediatric Histopathology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
4
Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom.
5
Department of Pathology, Cliniques Universitaires Saint Luc, Brussels, Belgium.
6
Department of Pediatric Endocrinology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom; Manchester Academic Health Science Centre, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.
7
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom. Electronic address: karen.e.cosgrove@manchester.ac.uk.

Abstract

Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.

PMID:
25444530
DOI:
10.1016/j.jpeds.2014.09.019
[Indexed for MEDLINE]
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