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Alzheimers Dement. 2015 Jan;11(1):1-15.e1-4. doi: 10.1016/j.jalz.2014.07.003. Epub 2014 Oct 28.

The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET.

Author information

1
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh. PA, USA. Electronic address: klunkwe@upmc.edu.
2
Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
3
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
4
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurosurgery, Washington University, Saint Louis, MO, USA.
5
Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
6
Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
7
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
8
Departments of Radiology, Pharmacology and Biological Chemistry, and Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
9
Avid Radiopharmaceuticals, Philadelphia, PA, USA.
10
Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, VIC, Australia.

Abstract

Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤ 45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale.

KEYWORDS:

Amyloid imaging; Centiloid scale; Pittsburgh compound B; Positron emission tomography; Standardize

PMID:
25443857
PMCID:
PMC4300247
DOI:
10.1016/j.jalz.2014.07.003
[Indexed for MEDLINE]
Free PMC Article

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