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Radiother Oncol. 2014 Oct;113(1):132-8. doi: 10.1016/j.radonc.2014.09.011. Epub 2014 Oct 15.

Peritumoral interstitial fluid flow velocity predicts survival in cervical carcinoma.

Author information

1
Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
2
Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
3
Department of Gynecological Cancer, Oslo University Hospital, Oslo, Norway; Institute for Medical Informatics, Oslo University Hospital, Oslo, Norway.
4
Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Electronic address: einar.k.rofstad@rr-research.no.

Abstract

BACKGROUND AND PURPOSE:

High tumor interstitial fluid pressure (IFP) is associated with poor outcome in locally advanced carcinoma of the uterine cervix. We have recently developed a noninvasive assay of the IFP of tumors, and in this assay, the outward interstitial fluid flow velocity at the tumor surface (v0) is measured by Gd-DTPA-based DCE-MRI and used as a parameter for IFP. Here, we investigated the independent prognostic significance of v0 in cervical cancer patients given cisplatin-based concurrent chemoradiotherapy with curative intent.

PATIENTS:

The study involved 62 evaluable patients from a cohort of 74 consecutive patients (Stage IB through IIIB) with a median follow-up of 5.5 years.

RESULTS:

The actuarial disease-free survival (DFS) and overall survival (OS) at 5 years were 67% and 76%, respectively. Significant associations were found between v0 dichotomized about the median value and DFS and OS, both in the total patient cohort and a subcohort of 40 Stage IIB patients. Multivariate analysis involving stage, tumor volume, lymph node status, and v0 revealed that only v0 provided independent prognostic information about DFS and OS.

CONCLUSION:

This investigation demonstrates a strong, independent prognostic impact of the pretreatment peritumoral fluid flow velocity in cervical cancer.

KEYWORDS:

Cervical carcinoma; DCE-MRI; Disease-free and overall survival; Interstitial fluid pressure; Peritumoral fluid flow

PMID:
25443501
DOI:
10.1016/j.radonc.2014.09.011
[Indexed for MEDLINE]

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