Bioorg Med Chem Lett. 2014 Nov 15;24(22):5164-9. doi: 10.1016/j.bmcl.2014.09.083. Epub 2014 Oct 6.

Bioactive compounds from the insect Aspongopus chinensis.

Shi YN¹, Tu ZC², Wang XL³, Yan YM¹, Fang P³, Zuo ZL³, Hou B³, Yang TH⁴, Cheng YX⁵.

Author information

1: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049, People's Republic of China.
2: Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, People's Republic of China.
3: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
4: Department of Hematology, First People's Hospital of Yunnan Province, Kunming 650032, People's Republic of China. Electronic address: ynanblood@aliyun.com.
5: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: yxcheng@mail.kib.ac.cn.

Abstract

Recent studies focusing on unveiling the biological agents of Aspongopus chinensis have led to the identification of four new norepinephrine derivatives (1-4), three new sesquiterpenoids (5-7), and one new lactam (8). In addition, twenty-three known compounds have been identified, most of which were isolated from this insect for the first time. Selected members of insect-derived substances were evaluated for their biological activities against renal protection in high-glucose-induced mesangial cells and COX-2 inhibition.