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Dig Liver Dis. 2014 Dec;46(12):1126-32. doi: 10.1016/j.dld.2014.09.004. Epub 2014 Oct 23.

Effects of 12 weeks of probiotic supplementation on quality of life in colorectal cancer survivors: a double-blind, randomized, placebo-controlled trial.

Author information

1
Department of Family Medicine, Yonsei University, College of Medicine, Republic of Korea.
2
Department of Clinical Nursing Science, Yonsei University, College of Nursing, Nursing Policy Research Institute, Biobehavioural Research Center, Republic of Korea.
3
Department of Sport and Leisure Studies, Sports Medicine Laboratory, Yonsei University, Republic of Korea.
4
Department of Family Medicine, Yonsei University, College of Medicine, Republic of Korea. Electronic address: indi5645@yuhs.ac.
5
Department of General Surgery, Yonsei University College of Medicine, Republic of Korea. Electronic address: namkyuk@yuhs.ac.

Abstract

BACKGROUND:

Probiotics may help resolve bowel symptoms and improve quality of life. We investigated the effects of 12 weeks of probiotics administration in colorectal cancer patients.

METHODS:

We conducted a double-blind, randomized, placebo-controlled trial. The participants took probiotics (Lacidofil) or placebo twice a day for 12 weeks. The cancer-related quality of life (FACT), patient's health-9 (PHQ-9), and bowel symptom questionnaires were completed by each participant.

RESULTS:

We obtained data for 32 participants in the placebo group and 28 participants in the probiotics group. The mean ages of total participants were 56.18 ± .86 years and 58.3% were male. Administration of probiotics significantly decreased the proportion of patients suffering from irritable bowel symptoms (0 week vs. 12 week; 67.9% vs. 45.7%, p=0.03), improved colorectal cancer-related FACT (baseline vs. 12 weeks: 19.79 ± 4.66 vs. 21.18 ± 3.67, p=0.04) and fatigue-related FACT (baseline vs. 12 weeks: 43.00 (36.50-45.50) vs. 44.50 (38.50-49.00), p=0.02) and PHQ-9 scores (0 weeks vs. 12 weeks; 3.00 (0-8.00) vs. 1.00 (0-3.00), p=0.01). We found significant differences in changes of the proportion of patients with bowel symptoms (p<0.05), functional well-being scores (p=0.04) and cancer-related FACT scores (p=0.04) between the two groups.

CONCLUSION:

Probiotics improved bowel symptoms and quality of life in colorectal cancer survivors.

KEYWORDS:

Bowel symptoms; Cancer survivors; Colorectal cancer; Probiotics

PMID:
25442120
DOI:
10.1016/j.dld.2014.09.004
[Indexed for MEDLINE]

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