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Metabolism. 2015 Feb;64(2):163-71. doi: 10.1016/j.metabol.2014.08.013. Epub 2014 Sep 10.

Dietary models of insulin resistance.

Author information

1
Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road Mail Code 111E, Phoenix, AZ 85012-1892. Electronic address: james.deer@dignityhealth.org.
2
Department of Endocrinology, Phoenix VA Health Care System, 650 E Indian School Road Mail Code 111E, Phoenix, AZ 85012-1892.

Abstract

Insulin resistance is a significant factor in the development of type 2 diabetes mellitus, however the connection between the Western diet and the development of insulin resistance has not been fully explained. Dietary macronutrient composition has been examined in a number of articles, and diets enriched in saturated fatty acids, and possibly in fructose, appear to be most consistently associated with the development of insulin resistance. However, mechanistic insights into the metabolic effects of such diets are lacking, and merit further study.

KEYWORDS:

Carbohydrate; Dietary composition; Fat; Insulin resistance

PMID:
25441706
DOI:
10.1016/j.metabol.2014.08.013
[Indexed for MEDLINE]

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