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Anal Chim Acta. 2014 Nov 19;850:6-25. doi: 10.1016/j.aca.2014.08.023. Epub 2014 Aug 17.

Recent advances in sample preparation techniques and methods of sulfonamides detection - A review.

Author information

1
Lomonosov Moscow State University, Chemistry Department, Leninskie gory, 1/3, 119991 Moscow, Russia. Electronic address: dmitrienko@analyt.chem.msu.ru.
2
Lomonosov Moscow State University, Chemistry Department, Leninskie gory, 1/3, 119991 Moscow, Russia.

Abstract

Sulfonamides (SAs) have been the most widely used antimicrobial drugs for more than 70 years, and their residues in foodstuffs and environmental samples pose serious health hazards. For this reason, sensitive and specific methods for the quantification of these compounds in numerous matrices have been developed. This review intends to provide an updated overview of the recent trends over the past five years in sample preparation techniques and methods for detecting SAs. Examples of the sample preparation techniques, including liquid-liquid and solid-phase extraction, dispersive liquid-liquid microextraction and QuEChERS, are given. Different methods of detecting the SAs present in food and feed and in environmental, pharmaceutical and biological samples are discussed.

KEYWORDS:

Extraction; Liquid chromatography–tandem mass spectrometry; Multi-class methods; Residue determination; Sample preparation; Sulfonamides

PMID:
25441155
DOI:
10.1016/j.aca.2014.08.023
[Indexed for MEDLINE]

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