Format

Send to

Choose Destination
Mayo Clin Proc. 2015 Jan;90(1):24-34. doi: 10.1016/j.mayocp.2014.08.021. Epub 2014 Nov 14.

Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials.

Author information

1
Department of Hypertension, Medical University of Lodz, Lodz, Poland. Electronic address: maciejbanach@aol.co.uk.
2
Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania; Centre for Interdisciplinary Research, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
3
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
5
Department of Nephrology, Hypertension, and Family Medicine, Medical University of Lodz, Lodz, Poland.
6
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.
7
Preventive Cardiology, CGH Medical Center, Sterling, IL.
8
Preventive Cardiology, CGH Medical Center, Sterling, IL; The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD.
9
Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
10
Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL.
11
University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK.
12
Centre for Interdisciplinary Research, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania; Department of Cardiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
13
Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London, London, UK.

Abstract

OBJECTIVE:

To evaluate the efficacy of coenzyme Q10 (CoQ10) supplementation on statin-induced myopathy.

PARTICIPANTS AND METHODS:

We searched the MEDLINE, Cochrane Library, Scopus, and EMBASE databases (November 1, 1987, to May 1, 2014) to identify randomized controlled trials investigating the impact of CoQ10 on muscle pain and plasma creatine kinase (CK) activity as 2 measures of statin-induced myalgia. Two independent reviewers extracted data on study characteristics, methods, and outcomes.

RESULTS:

We included 6 studies with 302 patients receiving statin therapy: 5 studies with 226 participants evaluated the effect of CoQ10 supplementation on plasma CK activity, and 5 studies (4 used in the CK analysis and 1 other study) with 253 participants were included to assess the effect of CoQ10 supplementation on muscle pain. Compared with the control group, plasma CK activity was increased after CoQ10 supplementation, but this change was not significant (mean difference, 11.69 U/L [to convert to μkat/L, multiply by 0.0167]; 95% CI, -14.25 to 37.63 U/L; P=.38). Likewise, CoQ10 supplementation had no significant effect on muscle pain despite a trend toward a decrease (standardized mean difference, -0.53; 95% CI, -1.33 to 0.28; P=.20). No dose-effect association between changes in plasma CK activity (slope, -0.001; 95% CI, -0.004 to 0.001; P=.33) or in the indices of muscle pain (slope, 0.002; 95% CI, -0.005 to 0.010; P=.67) and administered doses of CoQ10 were observed.

CONCLUSION:

The results of this meta-analysis of available randomized controlled trials do not suggest any significant benefit of CoQ10 supplementation in improving statin-induced myopathy. Larger, well-designed trials are necessary to confirm the findings from this meta-analysis.

PMID:
25440725
DOI:
10.1016/j.mayocp.2014.08.021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center