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Gastrointest Endosc. 2015 Mar;81(3):621-9. doi: 10.1016/j.gie.2014.09.008. Epub 2014 Oct 29.

Novel computer-aided diagnostic system for colorectal lesions by using endocytoscopy (with videos).

Author information

1
Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
2
Digestive Disease Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.

Abstract

BACKGROUND:

Endocytoscopy enables in vivo observation of nuclei at 450× magnification during GI endoscopy, thus allowing precise prediction of lesion pathology. However, because it requires training and experience, it may be beneficial only when performed by expert endoscopists.

OBJECTIVE:

To develop and evaluate a novel computer-aided diagnosis system for endocytoscopic imaging (EC-CAD) of colorectal lesions.

DESIGN:

Pilot study.

SETTING:

University hospital.

PATIENTS:

One hundred fifty-two patients with small colorectal polyps (≤10 mm) who had undergone endocytoscopy.

INTERVENTION:

Test sets of white-light endoscopic images and endocytoscopic images from 176 small colorectal polyps (137 neoplastic and 39 non-neoplastic polyps) were assessed by EC-CAD, 2 expert endoscopists, and 2 trainee endoscopists.

MAIN OUTCOME MEASUREMENT:

Sensitivity, specificity, and accuracy in predicting neoplastic change by EC-CAD comparing expert and trainee endoscopists.

RESULTS:

EC-CAD had a sensitivity of 92.0% and an accuracy of 89.2%; these were comparable to those achieved by expert endoscopists (92.7% and 92.3%; P = .868 and .256, respectively) and significantly higher than those achieved by trainee endoscopists (81.8% and 80.4%; P < .001 and .002, respectively). EC-CAD achieved a specificity of 79.5%; this did not differ significantly from that achieved by the experts and trainees. EC-CAD also enabled instant diagnosis, taking only 0.3 seconds for each lesion with perfect reproducibility.

LIMITATIONS:

No sample size calculation.

CONCLUSIONS:

EC-CAD provides fully automated instant classification of colorectal polyps with excellent sensitivity, accuracy, and objectivity. Thus, it can be a powerful tool for facilitating decision making during routine colonoscopy.

PMID:
25440671
DOI:
10.1016/j.gie.2014.09.008
[Indexed for MEDLINE]
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