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Surg Clin North Am. 2014 Dec;94(6):1151-61. doi: 10.1016/j.suc.2014.08.002. Epub 2014 Oct 7.

The opposing forces of the intestinal microbiome and the emerging pathobiome.

Author information

1
Center for Surgical Infection Research and Therapeutics, Department of Surgery, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Ave, MC 6040, Chicago, IL, USA.
2
Center for Surgical Infection Research and Therapeutics, Department of Surgery, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Ave, MC 6040, Chicago, IL, USA. Electronic address: jalverdy@surgery.bsd.uchicago.edu.

Abstract

This article summarizes emerging concepts on the role of the intestinal microbiome in surgical patients. Revolutionary research over the past decade has shown that human beings live in close and constant contact with boundless communities of microbes. Recent innovations in the study of the human microbiome are reviewed. To demonstrate the applicability of these studies to surgical disease, the authors discuss what is known about the role of microbes in the pathogenesis of perioperative complications. Enhanced awareness of the human microbiome will empower clinicians to adopt novel practices in the prevention and treatment of a variety of surgical conditions.

KEYWORDS:

Anastomotic leak; Bacteria; Infection; Metabolomics; Microbiome; Proteomics; Sepsis

PMID:
25440116
PMCID:
PMC4254556
DOI:
10.1016/j.suc.2014.08.002
[Indexed for MEDLINE]
Free PMC Article
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