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Cell Metab. 2014 Nov 4;20(5):699-700. doi: 10.1016/j.cmet.2014.10.014. Epub 2014 Nov 4.

Mammalian-microbial cometabolism of L-carnitine in the context of atherosclerosis.

Author information

1
Department of Food and Nutritional Sciences, The University of Reading, PO Box 226, Reading RG6 6AP, UK. Electronic address: s.p.claus@reading.ac.uk.

Abstract

γ-butyrobetaine has long been known as the precursor of endogenous L-carnitine synthesis. In this issue, Koeth et al. (2014) demonstrate that it is also a major metabolite of L-carnitine degradation by gut bacteria that precedes the enteric production of trimethylamine and trimethylamine-N-oxide.

PMID:
25440049
DOI:
10.1016/j.cmet.2014.10.014
[Indexed for MEDLINE]
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