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Nature. 1989 Jun 22;339(6226):597-603.

Structural parts involved in activation and inactivation of the sodium channel.

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1
Max-Planck-Institut für biophysikalische Chemie, Göttingen, FRG.

Abstract

Structure-function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site-directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage-sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.

PMID:
2543931
DOI:
10.1038/339597a0
[Indexed for MEDLINE]
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