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Clin Lab Med. 2014 Dec;34(4):747-61. doi: 10.1016/j.cll.2014.08.006. Epub 2014 Sep 15.

The changing landscape of the vaginal microbiome.

Author information

1
Department of Microbiology and Immunology, Center for the Study of Biological Complexity, 1101 East Marshall Street, PO Box 980678, Richmond, VA 23298, USA.
2
Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, PO Box 843083, Richmond, VA 23284, USA.
3
Department of Microbiology and Immunology, Center for the Study of Biological Complexity, 1101 East Marshall Street, PO Box 980678, Richmond, VA 23298, USA. Electronic address: gabuck@vcu.edu.

Abstract

Deep sequence analysis of the vaginal microbiome is revealing an unexpected complexity that was not anticipated as recently as several years ago. The lack of clarity in the definition of a healthy vaginal microbiome, much less an unhealthy vaginal microbiome, underscores the need for more investigation of these phenomena. Some clarity may be gained by the careful analysis of the genomes of the specific bacteria in these women. Ongoing studies will clarify this process and offer relief for women with recurring vaginal maladies and hope for pregnant women to avoid the experience of preterm birth.

KEYWORDS:

Bacterial vaginosis; Metagenomics; Microbiota; Pregnancy; Preterm birth; Vaginal microbiome

PMID:
25439274
PMCID:
PMC4254509
DOI:
10.1016/j.cll.2014.08.006
[Indexed for MEDLINE]
Free PMC Article

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