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Trends Microbiol. 2014 Nov;22(11):604-6. doi: 10.1016/j.tim.2014.10.001. Epub 2014 Oct 16.

A novel reverse genetics system for human norovirus.

Author information

1
Institute for Virology and Cell Biology, University of Lübeck, 23562 Lübeck, Germany.
2
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: cwobus@umich.edu.

Abstract

Human noroviruses cause significant morbidity, mortality, and economic losses worldwide. The inability to grow human noroviruses in cell culture has hampered our collective understanding of virus-host interactions and development of therapeutics. A newly described single-plasmid reverse genetics system for noroviruses has the potential to facilitate basic and applied research.

KEYWORDS:

generation of reporter-tagged viruses; norovirus reverse genetics system

PMID:
25438616
PMCID:
PMC4254560
DOI:
10.1016/j.tim.2014.10.001
[Indexed for MEDLINE]
Free PMC Article

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