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J Gen Virol. 1989 Jun;70 ( Pt 6):1605-8.

Antibody-dependent enhancement of yellow fever and Japanese encephalitis virus neurovirulence.

Author information

1
Arbovirus Research Unit, St Albans, Hertfordshire, U.K.

Abstract

Antibody-dependent enhancement of yellow fever virus neurovirulence, as measured by a reduction in the average survival time of groups of mice, was demonstrated with wild-type or vaccine strains of yellow fever virus and with Japanese encephalitis virus using intraperitoneally administered monoclonal antibodies specific for the viral E glycoprotein of yellow fever virus. Enhancement of virulence could be induced by neutralizing, non-neutralizing or protective antibodies if the virus was allowed to establish a productive infection in the mouse brain before the antibody was administered. The implications of antibody-dependent enhancement in flaviviruses are discussed.

PMID:
2543793
DOI:
10.1099/0022-1317-70-6-1605
[Indexed for MEDLINE]

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