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Cell Rep. 2014 Nov 6;9(3):1007-22. doi: 10.1016/j.celrep.2014.09.049. Epub 2014 Oct 23.

Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis.

Author information

1
Department of Developmental Biology, UT Southwestern Medical Center, Dallas, TX 75390-9133, USA.
2
Department of Developmental Biology, UT Southwestern Medical Center, Dallas, TX 75390-9133, USA; Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390-9133, USA. Electronic address: jon.graff@utsouthwestern.edu.

Abstract

Adipose tissues have striking plasticity, highlighted by childhood and adult obesity. Using adipose lineage analyses, smooth muscle actin (SMA)-mural cell-fate mapping, and conditional PPARγ deletion to block adipocyte differentiation, we find two phases of adipocyte generation that emanate from two independent adipose progenitor compartments: developmental and adult. These two compartments are sequentially required for organ formation and maintenance. Although both developmental and adult progenitors are specified during the developmental period and express PPARγ, they have distinct microanatomical, functional, morphogenetic, and molecular profiles. Furthermore, the two compartments derive from different lineages; whereas adult adipose progenitors fate-map from an SMA+ mural lineage, developmental progenitors do not. Remarkably, the adult progenitor compartment appears to be specified earlier than the developmental cells and then enters the already developmentally formed adipose depots. Thus, two distinct cell compartments control adipose organ development and organ homeostasis, which may provide a discrete therapeutic target for childhood and adult obesity.

PMID:
25437556
PMCID:
PMC4250841
DOI:
10.1016/j.celrep.2014.09.049
[Indexed for MEDLINE]
Free PMC Article

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