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Biomol Concepts. 2013 Aug;4(4):349-65. doi: 10.1515/bmc-2013-0007.

The molecular biology of selenocysteine.

Abstract

Selenium is an essential trace element that is incorporated into 25 human proteins as the amino acid selenocysteine (Sec). The incorporation of this amino acid turns out to be a fascinating problem in molecular biology because Sec is encoded by a stop codon, UGA. Layered on top of the canonical translation elongation machinery is a set of factors that exist solely to incorporate this important amino acid. The mechanism by which this process occurs, put into the context of selenoprotein biology, is the focus of this review.

PMID:
25436585
PMCID:
PMC4269102
DOI:
10.1515/bmc-2013-0007
[Indexed for MEDLINE]
Free PMC Article

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