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J Comp Pathol. 2015 Feb-Apr;152(2-3):172-6. doi: 10.1016/j.jcpa.2014.10.001. Epub 2014 Nov 27.

Absence of canine papillomavirus sequences in canine mammary tumours.

Author information

1
School of Veterinary Science, Alfonso X El Sabio University, Madrid, Spain.
2
School of Veterinary Science, University of Liverpool, Neston, UK.
3
Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Via Vienna 2, Sassari, Italy.
4
Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Via Vienna 2, Sassari, Italy. Electronic address: eantuofemo@uniss.it.

Abstract

Human papillomaviruses (PVs) are found in human breast cancer tissue; however, it remains controversial as to whether these viruses play a role in the aetiology of this tumour. There has been minimal study of whether PVs are found in normal or abnormal mammary glands of animals. The present study investigated whether a PV sequence could be found in the mammary glands of 33 female dogs by rolling circle amplification and polymerase chain reaction. No PV DNA was found in normal or neoplastic canine mammary tissues, suggesting that canine PVs are probably not involved in the pathogenesis of canine mammary neoplasia.

KEYWORDS:

dog; mammary tumour; papillomavirus

PMID:
25435511
DOI:
10.1016/j.jcpa.2014.10.001
[Indexed for MEDLINE]

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