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Nat Rev Microbiol. 2015 Jan;13(1):42-51. doi: 10.1038/nrmicro3380. Epub 2014 Dec 1.

Molecular mechanisms of antibiotic resistance.

Author information

1
1] Antimicrobials Research Group, School of Immunity and Infection, Institute for Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. [2].
2
Antimicrobials Research Group, School of Immunity and Infection, Institute for Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Abstract

Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.

PMID:
25435309
DOI:
10.1038/nrmicro3380
[Indexed for MEDLINE]
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